Taking Wegovy, Ozempic, or Mounjaro?

GLP-1 medications work incredibly well for weight loss - but clinical studies show 25-40% of the weight lost comes from muscle, not fat. Many patients regain the majority of lost weight within 12 months of stopping GLP-1 therapy. The primary reason is muscle loss during treatment, which reduces resting metabolic rate and makes weight regain almost inevitable. FORZET™ addresses this directly.

When treatment ends:

• Appetite returns into a body with slower metabolism
• Average 9.69kg weight regain within one year
• Regained weight is predominantly fat, not muscle

Whether you're just beginning or well into to treatment maintaining muscle should be part of your plan. Muscles can undermine progress and sustainability so protect it as soon as possible.

The most effective time to support muscle maintenance is before decline begins.

Research shows that up to 40%* of weight lost on GLP-1 medications may come from muscle tissue. When calorie intake is significantly reduced, essential amino acid availability can become insufficient to support normal muscle protein synthesis. FORZET™ provides essential amino acids formulated for exactly this nutritional context.

An evidence-based approach

Myosamin™ has been studied for over two decades in adults with hypercatabolic states. This is a condition where the body breaks down lean tissue faster than it can rebuild.

Inflammation, reduced food intake, increased metabolic demand (the body’s energy usage during illness, injury or chronic disease), prolonged inactivity or a combination of these factors can drive the body into this state. The result is the same: muscle becomes the first casualty.

GLP-1 therapy creates one such route. Appetite drops, intake falls faster than the body can manage, and survival takes priority. Your organs need energy to keep functioning, and muscle is sacrificed to fuel them. That is why muscle loss is the consequence.

Why essential amino acids

Muscles are dynamic tissue in a constant process of renewal: breakdown (catabolism) and formation (anabolism) should be in balance to prevent muscle loss. To produce muscle protein, the body needs specific amino acids as building blocks ("proteinogenic amino acids"). The body can produce most of these itself (non-essential amino acids), while the rest must be ingested. These are the essential amino acids.

On GLP-1 therapy, appetite is suppressed and food intake drops sharply. Trying to compensate by eating more protein-rich foods isn't a viable solution when you simply cannot eat enough.

And even if you could, the math doesn't work in your favour:

Supplementing other molecules that support protein synthesis only helps when the body has sufficient essential amino acids from food and on appetite-suppressing therapy, that supply is exactly what is missing.

Without essential amino acids, no protein synthesis can occur and no muscle can be built.

The evidence

Each study used rigorous trial designs similar to the standard used to evaluate medicines randomised, placebo-controlled studies, including crossover studies, one of the most powerful study designs where subjects receive treatments sequentially, with each serving as their own control.

Study settings included institutional rehabilitation after hospitalisation where each patient receives the same standard of care, from drug therapy to dietary modification and structured exercise. The difference to placebo observed in these studies comes entirely from our additional (to the best standard of care) intervention. The bar for evidence here is as high as nutritional science allows.