GLP-1 and Longevity
Forzet: Unlocking Longevity Through Health
At Metabio Kinetics Ltd., we believe that a healthy weight is only the starting point. In the UK, around 65% of adults are now overweight. Roughly one in four lives with obesity. GLP-1 medications can dramatically reduce weight. However, the real goal is to improve your healthspan (i.e., the years lived in good health) and not just move the number on the scale.
The FORZET™ Programme
The FORZET™ programme combines GLP-1 therapy with our proprietary Myosamin™-based medical food. The ultimate goal is to support both losing fat and increasing muscle for physical and mental health that supports a longer and healthier life.
Alternatively, you can define "healthy weight loss" as improving body composition. Obesity is not a disease of weight, but of adiposity.
UK and international cohort data show approximate average losses like these:
| Condition | Typical Years of Life Lost (YLL)* – UK / European data |
|---|---|
| Heart disease | 11 years of life on average compared with age-matched controls [R] |
| Cancers | Up to 13 years lost per cancer death on average [R] |
| Obesity and adiposity | Moderate obesity (BMI 30–35) shortens life expectancy by up to 3 years. Severe obesity (BMI 40–50) shortens life by up to 10 years [R] |
| Type 2 diabetes | A diagnosis made at the age of 50 is linked to up to 6 years shorter life expectancy, whereas a diagnosis at age 30 costs up to 13-14 years [R] |
| Fatty liver (NAFLD/MASLD) | Large European population-based data (Sweden) show NAFLD cuts life expectancy by 4-6 years when diagnosed in mid-life, which is generally extrapolated to UK metabolic-risk populations [R] |
| Chronic kidney disease (CKD), especially with diabetes and CVD | The combination of diabetes and major heart disease (very common in advanced CKD) has 12–16 years of life lost compared with someone of the same age without these conditions [R] |
Uncontrolled adiposity shortens life and healthspan. The good news is that it's largely acquired and can be improved with targeted interventions. At the same time, weight loss through muscle atrophy can backfire as it raises the risk of frailty, falls, loss of independence, and earlier onset of age-associated disease. Today, sarcopenia, which is an age-related loss of muscle mass, strength, and function, is increasingly recognised as a form of premature ageing that accelerates chronic illness and mortality.
Muscle is Medicine: Physical, Mental, and Metabolic Health
At Metabio Kinetics, we treat muscle as medicine. Skeletal muscle is the largest user of glucose in the body, which is indispensable for blood sugar control and insulin sensitivity.
Preserving and rebuilding muscle during GLP-1-driven weight loss will help to:
- Maintain a higher metabolic rate, which supports ongoing fat loss rather than a plateau.
- Improve strength, balance, and mobility, which reduces the risk of falls and fractures as people age.
- Support mental health: regular movement and stronger muscles are linked to better mood, energy, sleep, and cognitive function.
Myosamin™ is a clinically developed blend of essential and conditionally essential amino acids that aims to stimulate muscle protein synthesis. Clinical studies of products that contain Myosamin™ have shown improvements in muscle mass, strength, and exercise capacity, along with favourable effects on heart function and metabolic markers in specific patient groups.
The FORZET™ Programme: From Weight Loss to Weight Care
GLP-1 medications are fantastic for weight loss. However, they also reduce muscle mass and can cause a plateau and rebound when treatment stops.
FORZET™ can be a great addition to people's weight loss journeys:
-
During GLP-1 therapy, it supports muscle preservation, helps counter metabolic slowdown, and may reduce the risk of sarcopenia and the visible signs of premature ageing.
-
After GLP-1 therapy, it supports body recomposition (more muscle, less fat) to reduce rebound weight gain and help people maintain results.
In practical terms, this means:
-
Weight loss driven by GLP-1 medications triggers the reduction of excess fat.
-
Physical health is supported through clinically studied amino acids that help protect muscle, strength, and organ function.
-
Mental health and healthspan are supported by the gains in energy, mobility, confidence, and long-term metabolic resilience that come with healthier muscle and body composition.
With FORZET™, GLP-1 users in the UK can move from short-term "weight loss" to long-term weight care and longevity. The ultimate goal is to protect the muscle mass, reduce adiposity, and support a healthier future.